SIOP-PODC Recommended Graduated Intensity Guidelines for Diagnosis, Risk Stratification and Treatment of Neuroblastoma in Resource-Limited Countries

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TitleSIOP-PODC Recommended Graduated Intensity Guidelines for Diagnosis, Risk Stratification and Treatment of Neuroblastoma in Resource-Limited Countries
Publication TypeJournal Article
Year of Publication2015
AuthorsParikh, NS, Howard, SC, Chantada, G, Israels, T, Khattab, M, Alcasabas, P, Lam, C, Faulkner, L, Park, JR, London, WB, Matthay, KK
JournalPediatric Blood & Cancer
Volumein press
KeywordsDeveloping Countries, Neuroblastoma
Abstract

Neuroblastoma is the most common extracranial solid tumor in childhood in high-income countries (HIC), where consistency in treatment approaches based on clinical and tumor biological risk stratification has steadily improved outcomes.  However, in low- and middle- income countries (LMIC) approaches to diagnosis and treatments are inconsistent with incomplete risk-stratification due to limited resources resulting in poorer outcomes.    The clinical practice guidelines outlined in this manuscript are based on current evidence based literature, and expert opinions.   Standardization adapted to graduated resource settings will promote improved diagnosis, treatment assignments with improved outcome for children with neuroblastoma.

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